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经皮腔内冠状动脉成形术与冠状动脉搭桥手术——早期及随访临床结果

Percutaneous transluminal coronary angioplasty and coronary artery bypass surgery--early and follow-up clinical results.

作者信息

Kawazoe K, Haze K, Ohara K, Kosakai Y, Kito Y

机构信息

Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan.

出版信息

Jpn Circ J. 1991 Aug;55(8):809-14. doi: 10.1253/jcj.55.809.

Abstract

To evaluate the efficacies of percutaneous transluminal angioplasty (PTCA) and coronary artery bypass grafting (CABG) for angina pectoris, early and follow-up data were reviewed in 495 patients who had undergone these procedures from 1986 to 1988. In 173 patients with single vessel disease, there were no significant differences in initial success rate and early and late incidences of major complications or cardiac death between 152 patients with elective PTCA and 21 with urgent. When compared in 161 patients with multivessel disease, however, significant differences in success rate were found between 130 patients in the elective PTCA group and 31 in whom PTCA was urgent (81.6% vs. 64.5%, p less than 0.05). Significant differences were also found in early incidence of major complications (3.1% vs. 12.9%, p less than 0.01), early mortality (1.5% vs. 9.7%, p less than 0.01), and the late incidence of cardiac events (6.2% vs. 25.0%, p less than 0.01). These results show that freedom from cardiac death and overall cardiac events in the elective PTCA group as significantly better than that in the urgent group at 42 months of follow-up. Comparing early and follow-up results, on the other hand, there was no statistically significant difference between the elective and urgent CABG groups. Thus, there appear to be limitations on the urgent use of PTCA for refractory unstable angina caused by multivessel disease, and urgent CABG was recommended to high-risk patients of urgent PTCA.

摘要

为评估经皮腔内血管成形术(PTCA)和冠状动脉旁路移植术(CABG)治疗心绞痛的疗效,我们回顾了1986年至1988年间接受这两种手术的495例患者的早期及随访资料。在173例单支血管病变患者中,152例行择期PTCA的患者与21例行急诊PTCA的患者在初始成功率、主要并发症或心源性死亡的早期及晚期发生率方面无显著差异。然而,在161例多支血管病变患者中,择期PTCA组的130例患者与急诊PTCA的31例患者相比,成功率存在显著差异(81.6%对64.5%,p<0.05)。主要并发症的早期发生率(3.1%对12.9%,p<0.01)、早期死亡率(1.5%对9.7%,p<0.01)以及心脏事件的晚期发生率(6.2%对25.0%,p<0.01)也存在显著差异。这些结果表明,在42个月的随访中,择期PTCA组的心源性死亡和总体心脏事件发生率显著低于急诊组。另一方面,比较早期及随访结果,择期和急诊CABG组之间无统计学显著差异。因此,对于多支血管病变所致难治性不稳定型心绞痛,急诊使用PTCA似乎存在局限性,对于急诊PTCA的高危患者,建议行急诊CABG。

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