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[经皮腔内冠状动脉成形术与主动脉冠状动脉旁路移植术治疗不稳定型心绞痛和冠状动脉多支血管病变]

[Percutaneous transluminal coronary angioplasty and aortocoronary bypass surgery in unstable angina pectoris and coronary multivessel disease].

作者信息

Karsch K R, Jaeck U, Mauser M, Voelker W, Huth C, Fenchel G, Seboldt H, Hoffmeister H E, Seipel L

机构信息

Abteilung III, Universität Tübingen.

出版信息

Dtsch Med Wochenschr. 1987 Jan 15;113(2):49-52.

PMID:2962848
Abstract

In 113 patients demonstrating the clinical syndrome of unstable angina, acute-stage coronary angiography revealed multivessel disease. Acute PTCA of the ischaemia-related coronary artery or bypass grafting was performed depending on angiographic criteria. Of the total of 68 patients in whom PTCA was performed, 45 had two-vessel disease (2 vd) and 23 three-vessel disease (3 vd). 12 of the 45 patients with bypass operation had a left main stem stenosis, whereas 33 had three-vessel disease. The primary success rate of PTCA was 81%, 89% in patients with 2 vd and 70% in patients with 3 vd. Acute post-PTCA bypass grafting was necessary in 2 patients having 2 vd and in 5 patients suffering from 3 vd. 5 of the 68 patients treated with PTCA developed a transmural myocardial infarct and one patient died after PTCA and emergency bypass surgery. 8 of the 45 operated patients had a perioperative or postoperative myocardial infarct and 5 patients died intraoperatively or postoperatively. The overall morbidity was 11.5%, and the mortality of hospitalised patients was 5.3% (6/113). Combination of PTCA with emergency bypass grafting offers a new and effective treatment with an acceptable risk even in multivessel disease patients and in those having unstable angina pectoris. The additional use of PTCA definitely improves therapeutic management in this high-risk population.

摘要

在113例表现为不稳定型心绞痛临床综合征的患者中,急性期冠状动脉造影显示多支血管病变。根据血管造影标准,对缺血相关冠状动脉进行急性经皮冠状动脉腔内血管成形术(PTCA)或冠状动脉搭桥术。在总共68例行PTCA的患者中,45例为双支血管病变(2 vd),23例为三支血管病变(3 vd)。45例行搭桥手术的患者中,12例有左主干狭窄,33例有三支血管病变。PTCA的首次成功率为81%,2 vd患者为89%,3 vd患者为70%。2例2 vd患者和5例3 vd患者在PTCA后需要进行急性冠状动脉搭桥术。68例接受PTCA治疗的患者中有5例发生透壁性心肌梗死,1例患者在PTCA及急诊搭桥手术后死亡。45例接受手术的患者中有8例发生围手术期或术后心肌梗死,5例患者在术中或术后死亡。总体发病率为11.5%,住院患者死亡率为5.3%(6/113)。PTCA与急诊冠状动脉搭桥术联合应用为多支血管病变患者及不稳定型心绞痛患者提供了一种新的、有效的治疗方法,且风险可接受。在这一高危人群中,额外使用PTCA肯定能改善治疗管理。

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