Shimamoto Y, Shimamoto H, Nakamura H
Department of Internal Medicine, Nakamura Hospital.
Nihon Ronen Igakkai Zasshi. 1991 May;28(3):385-91. doi: 10.3143/geriatrics.28.385.
The effects of a two-week high sodium diet on mitral flow pattern were assessed in 29 patients with essential hypertension (81.9 +/- 6.9 years). Transmitral flow was recorded during different rates of salt intake; 7 g/day for 8 weeks and 20 g/day for 2 weeks. With sodium loading, 25 patients whose mean blood pressure (MBP) increased by 10 percent or more were termed salt-sensitive (SS) group, and 4 patients whose MBP did not change or increased by less than 10 percent were termed non-salt-sensitive (NSS) group with mitral flow velocity integral, cardiac output (CO) and total peripheral resistance (TPR) were calculated. Thirteen of the SS patients were defined as "SST" in which an increase in TPR was greater than that in CO with sodium repletion. In the remaining 12 SS patients termed "SSc", the increase in CO was greater than that in TPR with salt loading. CO increased significantly in the SSc patients, but did not change in the SST or NSS group with sodium loading. TPR increased significantly in the SST and NSS subjects, and decreased significantly in the SSc patients. Peak velocity of transmitral flow in the rapid filling phase (R) decreased significantly in the SST and NSS patients, and increased significantly in the SSc group. On the other hand peak velocity of transmitral flow in the atrial contraction phase (A) increased significantly in the SST and SSc groups, but remained unchanged in the NSS patients. There was a significant increase in A/R in the SSt group and a significant decrease in A/R in the SSc patients with sodium loading.
在29例原发性高血压患者（81.9±6.9岁）中评估了为期两周的高钠饮食对二尖瓣血流模式的影响。在不同盐摄入量期间记录经二尖瓣血流；8周内每天摄入7克，2周内每天摄入20克。随着钠负荷增加，25例平均血压（MBP）升高10%或更多的患者被称为盐敏感（SS）组，4例MBP未变化或升高不到10%的患者被称为非盐敏感（NSS）组，并计算二尖瓣血流速度积分、心输出量（CO）和总外周阻力（TPR）。13例SS患者被定义为“SST”，即钠补充后TPR的增加大于CO的增加。在其余12例称为“SSc”的SS患者中，盐负荷后CO的增加大于TPR的增加。SSc患者的CO显著增加，但钠负荷后SST或NSS组无变化。SST和NSS受试者的TPR显著增加，而SSc患者的TPR显著降低。快速充盈期（R）二尖瓣血流峰值速度在SST和NSS患者中显著降低，而在SSc组中显著增加。另一方面，心房收缩期（A）二尖瓣血流峰值速度在SST和SSc组中显著增加，但在NSS患者中保持不变。钠负荷后，SSt组A/R显著增加，SSc患者A/R显著降低。
