Shimamoto H, Shimamoto Y
First Department of Internal Medicine, Hiroshima University School of Medicine.
Kokyu To Junkan. 1991 May;39(5):475-80.
Three-week effects of a high sodium diet on mitral flow pattern were assessed in 23 patients with essential hypertension (81.8 +/- 6.8 years). Transmitral flow was recorded during different rates of salt intake: 7 g/day for 8 weeks, 20 g/day for 3 weeks. With sodium loading, 19 patients whose mean blood pressure (MBP) increased by 10 percent or more were termed the salt-sensitive (SS) group, and 4 patients whose MBP did not change, or increased by less than 10 percent were termed the non salt-sensitive (NSS) group. With mitral velocity integral, cardiac output (CO) and total peripheral resistance (TPR) were calculated. Fourteen of the SS patients, in which an increase in TPR was greater than that in CO with sodium repletion, were defined as "SST". In the remaining 5 SS patients, termed "SSC", an increase in CO was greater than that in TPR with salt loading. CO increased significantly in the SSC patients, but did not change in the SST or NSS group with sodium loading. TPR increased significantly in the SST, and remained unchanged in the SSC or NSS patients. Peak velocity of transmitral flow in the rapid filling phase (R) decreased significantly in the SST patients, increased significantly in the SSC group, and remained unchanged in the NSS subjects. While, peak velocity of transmitral flow in the atrial contraction phase (A) increased significantly in the SSC group, it remained unchanged in the SST and NSS patients. There was a significant increase in A/R in the SST group and a significant decrease in A/R in the SSC patients with sodium loading.
在23例原发性高血压患者（81.8±6.8岁）中评估了高钠饮食对二尖瓣血流模式的三周影响。在不同盐摄入量时记录二尖瓣血流：8周内每天7克，3周内每天20克。随着钠负荷增加，19例平均血压（MBP）升高10%或更多的患者被称为盐敏感（SS）组，4例MBP未改变或升高不到10%的患者被称为非盐敏感（NSS）组。通过二尖瓣速度积分计算心输出量（CO）和总外周阻力（TPR）。14例SS患者，钠补充后TPR的增加大于CO的增加，被定义为“SST”。在其余5例SS患者中，称为“SSC”，盐负荷时CO的增加大于TPR的增加。SSC组患者的CO显著增加，但钠负荷时SST组或NSS组未改变。SST组TPR显著增加，SSC组或NSS组患者TPR保持不变。SST组患者快速充盈期二尖瓣血流峰值速度（R）显著降低，SSC组显著增加，NSS组患者保持不变。同时，SSC组心房收缩期二尖瓣血流峰值速度（A）显著增加，SST组和NSS组患者保持不变。钠负荷时，SST组A/R显著增加，SSC组患者A/R显著降低。
