Shimamoto H, Shimamoto Y
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
J Hum Hypertens. 1992 Oct;6(5):353-8.
Thirty-four elderly patients were studied using a Doppler flowmeter during different sodium intakes. Salt increased mean blood pressure and cardiac output (CO), while total peripheral resistance (TPR) remained unchanged. Neither carotid nor terminal aortic resistance changed, while coeliac, superior mesenteric or renal resistance increased. There was a significant and direct correlation (r = 0.82) between the change in TPR and that in terminal aortic resistance. Salt-sensitive patients were divided into two subgroups; the SST group in which sodium loading increased TPR more than CO, and the SSC group in which salt loading increased CO more than TPR. Terminal aortic resistance increased in the SST, decreased in the SSC, and remained unchanged in the non-salt-sensitive group with salt loading. The terminal aortic vascular bed received much of the increase of CO in the SSC patients. In the SST group, the contribution of the individual vascular area to increased TPR was assessed, which revealed that terminal aortic response to sodium loading was the major determinant of increased TPR. We concluded that the responses of terminal aortic vascular bed to sodium loading contributed to the changes in TPR.
在不同钠摄入量期间，使用多普勒流量计对34名老年患者进行了研究。盐会增加平均血压和心输出量（CO），而总外周阻力（TPR）保持不变。颈动脉阻力和主动脉末端阻力均未改变，而腹腔干、肠系膜上动脉或肾阻力增加。TPR的变化与主动脉末端阻力的变化之间存在显著的直接相关性（r = 0.82）。盐敏感患者分为两个亚组；钠负荷增加时TPR升高幅度大于CO的SST组，以及盐负荷增加时CO升高幅度大于TPR的SSC组。盐负荷时，SST组主动脉末端阻力增加，SSC组降低，非盐敏感组保持不变。在SSC患者中，主动脉末端血管床接受了大部分增加的心输出量。在SST组中，评估了各个血管区域对TPR增加的贡献，结果显示主动脉末端对钠负荷的反应是TPR增加的主要决定因素。我们得出结论，主动脉末端血管床对钠负荷的反应导致了TPR的变化。
