Iciek R, Wender-Ozegowska E, Seremak-Mrozikiewicz A, Drews K, Sodowski K, Pietryga M, Brazert J
Department of Obstetrics and Women Diseases, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
J Physiol Pharmacol. 2008 Sep;59 Suppl 4:19-31.
There have been several genetic causes of obesity discussed by past authors, among others leptin, that have provided information regarding signaling pathways in energy expenditure in humans. Genetic variants of the leptin gene and its receptor may influence body weight.
To investigate the role of the leptin gene's polymorphism promotion region (2548 G/A) and the leptin gene receptor polymorphism (668 A/G) and its associations with body weight in pregnant women with type 1 diabetes (PGDM-1).
78 PGDM-1 were qualified to the study group (SG) which was divided into normal and over-weight individuals according to BMI criteria. The control group (CG) consisted of first trimester healthy pregnant women with normal body weight. Genetic variants of the leptin gene and its receptor were analyzed using PCR-RFLP assays. Within the SG, the following metabolic parameters were estimated: MBG, HbA1C, insulin dose, LDL, HDL, T-CHOL, creatinine, creatinine clearance and blood pressure.
There was a trend found among the majority of homozygous A and G variants in LEP -2548 G/A and LEPR 668 A/G in over-weight and obese individuals in comparison to normal-weight subjects (CG). There were no specific differences found in selected first trimester metabolic parameters in relation to patients' genotypes.
过去的作者讨论过肥胖的几种遗传原因，其中包括瘦素，它提供了有关人类能量消耗信号通路的信息。瘦素基因及其受体的基因变异可能会影响体重。
研究瘦素基因多态性促进区（2548 G/A）和瘦素基因受体多态性（668 A/G）在1型糖尿病孕妇（PGDM-1）中的作用及其与体重的关系。
78名PGDM-1患者被纳入研究组（SG），根据BMI标准分为正常体重和超重个体。对照组（CG）由孕早期体重正常的健康孕妇组成。使用PCR-RFLP分析方法分析瘦素基因及其受体的基因变异。在SG组内，评估以下代谢参数：空腹血糖、糖化血红蛋白、胰岛素剂量、低密度脂蛋白、高密度脂蛋白、总胆固醇、肌酐、肌酐清除率和血压。
与正常体重受试者（CG）相比，超重和肥胖个体中LEP -2548 G/A和LEPR 668 A/G的大多数纯合A和G变异之间存在一种趋势。在所选的孕早期代谢参数方面，未发现与患者基因型有特定差异。
