Department of Obstetrics and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
J Physiol Pharmacol. 2013 Oct;64(5):579-85.
Type 1 diabetes mellitus (T1DM) is still associated with increased risk for severe maternal and fetal complications but their pathomechanism remains unclear. We investigated into possible role of placental leptin (LEP) and its receptor gene (LEPR) in T1DM pregnancies. Fourty nine pregnant women with T1DM and singleton pregnancy were enrolled into the study. Control group consisted of 15 healthy pregnant women in uncomplicated, singleton gestation. We observed higher expression of LEP and LEPR in T1DM placentas in comparison to healthy subjects. We also noticed greater expression of LEP and LEPR in T1DM pregnancies with large for gestational age (LGA) and appropriate for gestational age (AGA) fetuses in comparison to small for gestational age (SGA) diabetic fetuses and controls. We found a significant positive correlation between placental LEP and LEPR expression and neonatal birthweight in overweight T1DM subjects. No such a correlation was found in T1DM subjects with normal weight and controls. We conclude that increased placental LEP and LEPR expression may have a role in stimulating fetal overgrowth in T1DM pregnancy.
1 型糖尿病（T1DM）仍然与严重的母婴并发症风险增加有关，但其发病机制仍不清楚。我们研究了胎盘瘦素（LEP）及其受体基因（LEPR）在 T1DM 妊娠中的可能作用。将 49 名患有 T1DM 和单胎妊娠的孕妇纳入研究。对照组由 15 名健康孕妇组成，均为非复杂、单胎妊娠。与健康受试者相比，我们观察到 T1DM 胎盘中的 LEP 和 LEPR 表达更高。我们还注意到，与 SGA 糖尿病胎儿和对照组相比，T1DM 妊娠中 LGA 和 AGA 胎儿的 LEP 和 LEPR 表达更高。我们发现，超重 T1DM 受试者的胎盘 LEP 和 LEPR 表达与新生儿出生体重呈显著正相关。在 T1DM 体重正常的受试者和对照组中没有发现这种相关性。我们的结论是，胎盘 LEP 和 LEPR 表达的增加可能在 T1DM 妊娠中刺激胎儿过度生长中起作用。
