Decembrini Sarah, Andreazzoli Massimiliano, Barsacchi Giuseppina, Cremisi Federico
Department of Biology, University of Pisa, Italy.
Int J Dev Biol. 2008;52(8):1099-103. doi: 10.1387/ijdb.082646sd.
Maturation of miRNAs by dicer is required in vertebrates for normal neural development. Here we report that dicer inactivation in Xenopus affects cell cycle progression, survival and timing of the generation of retinal cells, resulting in small retinas with lamination defects. In particular, dicer inactivation delays the exit from the cell cycle and the translation of key genes of late neurogenesis, highlighting a crucial role of miRNAs in retinal development.
在脊椎动物中，Dicer使微小RNA（miRNA）成熟对于正常的神经发育是必需的。在此我们报告，非洲爪蟾中Dicer的失活会影响细胞周期进程、视网膜细胞生成的存活及时间，导致视网膜变小并伴有分层缺陷。特别地，Dicer失活会延迟细胞周期退出以及晚期神经发生关键基因的翻译，这突出了miRNA在视网膜发育中的关键作用。
