Wilson Andrew D H, Mercer Nigel
Department of Plastic Surgery, Frenchay Hospital, Frenchay, Bristol, United Kingdom.
Cleft Palate Craniofac J. 2008 Nov;45(6):614-9. doi: 10.1597/07-072.1. Epub 2008 Jan 23.
The purpose of this study was to compare the infection and hypertrophic scar rates in unilateral cleft lip repairs, having had Steri-Strips or Dermabond tissue glue applied across the repair as the final stage.
Retrospective study over 13 years of 307 unilateral cleft lip repairs by a single surgeon. The application of either Steri-Strips from 1992 to 1998 (121 patients) or Dermabond tissue adhesive from 1998 to 2006 (186 patients) was used in the final stage of the repair.
Regional Centre for Cleft Lip and Palate Care, South West of England.
307 consecutive unilateral cleft lip patients seen from 1992 to 2006.
There were five (4%) infections in the Steri-Strip group. All infections were with Staphylococcus aureus. No infections occurred in the Dermabond group (p< .001). There were 15 (12%) hypertrophic scars in the Steri-Strip group and 33 (18%) hypertrophic scars in the Dermabond group (p= .142). Revision surgery was required in a total of seven (6%) patients in the Steri-Strip group. No revisions were required in the Dermabond group (p. 1).
We found a lower infection and revision rate and a similar hypertrophic scar rate when Dermabond was used instead of Steri-Strips in the final stage of unilateral cleft lip repair and suggest this study further supports the use of octyl-2-cyanoacrylate tissue adhesive in unilateral cleft lip repair.
本研究旨在比较在单侧唇裂修复手术最后阶段使用皮肤缝合胶带（Steri-Strips）或皮肤粘合剂（Dermabond）时的感染率和肥厚性瘢痕发生率。
对一位外科医生在13年间进行的307例单侧唇裂修复手术进行回顾性研究。在修复手术的最后阶段，1992年至1998年对121例患者使用了皮肤缝合胶带，1998年至2006年对186例患者使用了皮肤粘合剂。
英格兰西南部唇腭裂护理区域中心。
1992年至2006年连续收治的307例单侧唇裂患者。
皮肤缝合胶带组有5例（4%）发生感染。所有感染均由金黄色葡萄球菌引起。皮肤粘合剂组未发生感染（p<0.001）。皮肤缝合胶带组有15例（12%）出现肥厚性瘢痕，皮肤粘合剂组有33例（18%）出现肥厚性瘢痕（p=0.142）。皮肤缝合胶带组共有7例（6%）患者需要进行修复手术。皮肤粘合剂组无需进行修复手术（p=0.1）。
我们发现在单侧唇裂修复手术的最后阶段使用皮肤粘合剂而非皮肤缝合胶带时，感染率和修复率较低，肥厚性瘢痕发生率相似，并表明本研究进一步支持在单侧唇裂修复中使用2-氰基丙烯酸辛酯组织粘合剂。
