Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Giessen, Germany.
Neurosurg Rev. 2010 Oct;33(4):483-9. doi: 10.1007/s10143-010-0258-5. Epub 2010 May 4.
It is claimed that wound closure with 2-octyl-cyanoacrylate has the advantages that band-aids are not needed in the postoperative period, that the wound can get in contact with water and that removal of stitches is not required. This would substantially enhance patient comfort, especially in times of reduced in-hospital stays. Postoperative wound infection is a well-known complication in spinal surgery. The reported infection rates range between 0% and 12.7%. The question arises if the advantages of wound closure with 2-octyl-cyanoacrylate in spinal surgery are not surpassed by an increase in infection rate. This study has been conducted to identify the infection rate of spinal surgery if wound closure was done with 2-octyl-cyanoacrylate. A total of 235 patients with one- or two-level surgery at the cervical or lumbar spine were included in this prospective study. Their pre- and postoperative course was evaluated. Analysis included age, sex, body mass index, duration and level of operation, blood examinations, 6-week follow-up and analysis of preoperative risk factors. The data were compared to infection rates of similar surgeries found in a literature research and to a historical group of 503 patients who underwent wound closure with standard skin sutures after spine surgery. With the use of 2-octyl-cyanoacrylate, only one patient suffered from postoperative wound infection which accounts for a total infection rate of 0.43%. In the literature addressing infection rate after spine surgery, an average rate of 3.2% is reported. Infection rate was 2.2% in the historical control group. No risk factor could be identified which limited the usage of 2-octyl-cyanoacrylate. 2-Octyl-cyanoacrylate provides sufficient wound closure in spinal surgery and is associated with a low risk of postoperative wound infection.
据称，使用 2-辛基氰基丙烯酸酯进行伤口闭合具有以下优点：术后无需使用创可贴，伤口可以接触水，也无需拆线。这将极大地提高患者的舒适度，尤其是在住院时间缩短的情况下。术后伤口感染是脊柱手术中已知的并发症。报告的感染率在 0%到 12.7%之间。问题是，如果使用 2-辛基氰基丙烯酸酯进行伤口闭合的优势不能超过感染率的增加，那么在脊柱手术中使用 2-辛基氰基丙烯酸酯进行伤口闭合的优势是否还存在。本研究旨在确定使用 2-辛基氰基丙烯酸酯进行伤口闭合时脊柱手术的感染率。共有 235 例接受颈椎或腰椎 1 至 2 个节段手术的患者纳入本前瞻性研究。评估了他们的术前和术后过程。分析包括年龄、性别、体重指数、手术时间和水平、血液检查、6 周随访和术前危险因素分析。将这些数据与文献中类似手术的感染率以及接受脊柱手术后使用标准皮肤缝线进行伤口闭合的 503 例历史组患者的感染率进行了比较。使用 2-辛基氰基丙烯酸酯，只有 1 例患者发生术后伤口感染，总感染率为 0.43%。在涉及脊柱手术后感染率的文献中，报告的平均感染率为 3.2%。历史对照组的感染率为 2.2%。没有发现限制使用 2-辛基氰基丙烯酸酯的危险因素。2-辛基氰基丙烯酸酯在脊柱手术中提供了充分的伤口闭合，并与术后伤口感染的低风险相关。
