Bohne B D, Barz B, Schölzel-Klatt A, Kästner R
Charité-Augenklinik Berlin.
Klin Monbl Augenheilkd. 1991 Jun;199(1):30-5. doi: 10.1055/s-2008-1046042.
This paper attempts to obtain a better understanding of the oxygen supply to tissue cells of the optic nerve head by describing all phases of the release, diffusion and consumption process by means of a mathematical model. As a result the oxygen partial pressure reduction induced by intraocular pressure elevation--as it occurs in glaucoma--seems to be mainly influenced by a pressure-induced lowering of the average blood velocity in the retinal capillaries. A reduction of this velocity to a fourth of its normal value even makes the oxygen partial pressure at the venous capillary wall drop below the critical level necessary for maintaining cell activity. Furthermore our calculations allow us to conclude that an involvement of the retinal capillary network supplied by the central retinal artery should not be neglected in glaucoma.
本文试图通过数学模型描述氧气释放、扩散和消耗过程的各个阶段，从而更好地理解视神经乳头组织细胞的氧气供应情况。结果表明，眼压升高（如青光眼患者那样）所导致的氧分压降低，似乎主要受视网膜毛细血管平均血流速度因压力而降低的影响。血流速度降至正常值的四分之一时，甚至会使静脉毛细血管壁处的氧分压降至维持细胞活动所需的临界水平以下。此外，我们的计算结果使我们得出结论，在青光眼的研究中，不应忽视由视网膜中央动脉供血的视网膜毛细血管网络所起的作用。
