Barrell Daniel, Dimmer Emily, Huntley Rachael P, Binns David, O'Donovan Claire, Apweiler Rolf
Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Res. 2009 Jan;37(Database issue):D396-403. doi: 10.1093/nar/gkn803. Epub 2008 Oct 27.
The Gene Ontology Annotation (GOA) project at the EBI (http://www.ebi.ac.uk/goa) provides high-quality electronic and manual associations (annotations) of Gene Ontology (GO) terms to UniProt Knowledgebase (UniProtKB) entries. Annotations created by the project are collated with annotations from external databases to provide an extensive, publicly available GO annotation resource. Currently covering over 160 000 taxa, with greater than 32 million annotations, GOA remains the largest and most comprehensive open-source contributor to the GO Consortium (GOC) project. Over the last five years, the group has augmented the number and coverage of their electronic pipelines and a number of new manual annotation projects and collaborations now further enhance this resource. A range of files facilitate the download of annotations for particular species, and GO term information and associated annotations can also be viewed and downloaded from the newly developed GOA QuickGO tool (http://www.ebi.ac.uk/QuickGO), which allows users to precisely tailor their annotation set.
欧洲生物信息研究所（EBI）的基因本体注释（GOA）项目（http://www.ebi.ac.uk/goa）为通用蛋白质知识库（UniProtKB）条目提供了高质量的电子和人工关联（注释）的基因本体（GO）术语。该项目创建的注释与来自外部数据库的注释进行整理，以提供一个广泛的、公开可用的GO注释资源。目前涵盖超过16万个分类单元，拥有超过3200万个注释，GOA仍然是基因本体联盟（GOC）项目中最大且最全面的开源贡献者。在过去五年中，该团队增加了其电子流程的数量和覆盖范围，并且一些新的人工注释项目和合作现在进一步增强了这一资源。一系列文件便于下载特定物种的注释，并且GO术语信息和相关注释也可以从新开发的GOA QuickGO工具（http://www.ebi.ac.uk/QuickGO）中查看和下载，该工具允许用户精确定制他们的注释集。
