Nishimura M, Kaku K, Azuno Y, Okafuji K, Etoh Y, Shiozaki M, Sasaki H, Inoue T, Kaneko T
Department of Pediatrics, Yokohama City University, School of Medicine, Japan.
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1042-7. doi: 10.1016/0006-291x(91)92042-i.
To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis.
为评估红系分化因子（EDF）对巨核细胞生成的显著作用，检测了EDF对小鼠巨核母细胞系L8057巨核细胞分化的影响。EDF以剂量依赖性方式增强L8057的乙酰胆碱酯酶（AchE）诱导作用。EDF对巨核细胞分化的作用强度与先前报道的对红系分化的作用强度相当。目前的结果表明，EDF可能在巨核细胞生成以及红细胞生成中发挥调节作用。
