Meisel C, Höflich C, Volk H-D
Institut für Medizinische Immunologie, Charité Universitätsmedizin Berlin, Campus Mitte, 10117 Berlin.
Dtsch Med Wochenschr. 2008 Nov;133(45):2332-6. doi: 10.1055/s-0028-1100924. Epub 2008 Oct 28.
Sepsis is a life-threatening disease characterized by a complex interaction between pathogens and the immune system. The analysis of immune parameters in patients with sepsis or at risk for sepsis may help to identify predisposing factors and infection-specific reaction patterns, as well as to monitor the current functional state of the immune system. This may lead to personalized therapeutic strategies for improving outcome in sepsis. Based on the PIRO model (predisposition, insult, response, organ dysfunction), a pathophysiologically-oriented concept for the development of a new sepsis classification, this article reviews currently used and new parameters for immunomonitoring in SIRS (systemic inflammatory response syndrome) and sepsis.
脓毒症是一种危及生命的疾病，其特征是病原体与免疫系统之间存在复杂的相互作用。对脓毒症患者或有脓毒症风险患者的免疫参数进行分析，可能有助于识别易感因素和感染特异性反应模式，以及监测免疫系统的当前功能状态。这可能会带来改善脓毒症预后的个性化治疗策略。基于PIRO模型（易感性、损伤、反应、器官功能障碍），这是一种针对新的脓毒症分类发展的病理生理学导向概念，本文综述了目前在全身炎症反应综合征（SIRS）和脓毒症中用于免疫监测的现有参数和新参数。
