Goyal Abhinav, Nerenberg Kara, Gerstein Hertzel C, Umpierrez Guillermo, Wilson Peter W F
Department of Epidemiology, Emory Rollins School of Public Health, Atlanta, GA, USA.
Diab Vasc Dis Res. 2008 Nov;5(4):276-84. doi: 10.3132/dvdr.2008.040.
Insulin therapy was first proposed as an adjunctive therapy in patients with acute coronary syndromes (ACS) in the 1960s. Since then, numerous randomised clinical trials have been conducted to determine the efficacy and to define the role of insulin therapy in ACS. This review will discuss: 1) completed trials of insulin therapy in ACS, including both glucose-insulin-potassium (GIK) approaches and non-GIK approaches; 2) trials of insulin therapy in critically ill non-ACS patients and the lessons from these trials that can be applied to trials of insulin in ACS patients; and 3) a summary of ongoing and planned trials of insulin in ACS patients.
胰岛素疗法在20世纪60年代首次被提议作为急性冠脉综合征（ACS）患者的辅助治疗方法。从那时起，已经进行了大量随机临床试验，以确定胰岛素疗法的疗效并明确其在ACS中的作用。本综述将讨论：1）ACS中胰岛素疗法的已完成试验，包括葡萄糖-胰岛素-钾（GIK）方案和非GIK方案；2）危重症非ACS患者的胰岛素疗法试验以及这些试验中可应用于ACS患者胰岛素试验的经验教训；3）ACS患者正在进行和计划进行的胰岛素试验总结。
