[Spontaneous neoplastic transformation of laryngeal papilloma in adults].

The process of spontaneous malignancy of laryngeal papilloma in 80 adults was analysed: 36 with juvenile papilloma and 44 with hyperkeratotic papilloma. In all of the cases, surgical removed material was serially examined histopathological to observe very early process of cancerogenesis of a different degree of cellular dysplasia. In clinical evidence, cases with juvenile papilloma had leukoplakia on the surface of the papillomas. Only in two cases with numerous recurrences were leukoplakia and dysplasia of cells permanent and only one showed a fully developed carcinoma. Hyperkeratotic papillomas are undoubtedly a pre-carcinoma condition, because 70.5% of cases revealed evidence of becoming malignant idiopathically. Malignancy had its beginning in deep base layers. There were two possibilities of developing papilloma hyperkeratotic: carcinoma spinocellular or carcinoma verrucosum.