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Delineating an epigenetic continuum in head and neck cancer.描绘头颈部癌症中的表观遗传学连续统。
Cancer Lett. 2014 Jan 28;342(2):178-84. doi: 10.1016/j.canlet.2012.02.018. Epub 2012 Mar 1.
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[Epigenetic aspects in carcinomas of the head and neck].[头颈部癌的表观遗传学方面]
HNO. 2008 Jun;56(6):594-602. doi: 10.1007/s00106-008-1720-3.
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Aberrant methylation inactivates somatostatin and somatostatin receptor type 1 in head and neck squamous cell carcinoma.异常甲基化使头颈部鳞状细胞癌中的生长抑素和1型生长抑素受体失活。
PLoS One. 2015 Mar 3;10(3):e0118588. doi: 10.1371/journal.pone.0118588. eCollection 2015.
4
Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene.头颈部鳞状细胞癌：错配修复免疫组织化学和 hMLH1 基因启动子超甲基化。
Am J Otolaryngol. 2011 Nov-Dec;32(6):528-36. doi: 10.1016/j.amjoto.2010.11.005. Epub 2011 Feb 24.
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Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival.对头颈鳞状细胞癌进行全面基因组分析，揭示 FGFR1 扩增和肿瘤基因组改变负担可作为生存预后的生物标志物。
Eur J Cancer. 2018 Mar;91:47-55. doi: 10.1016/j.ejca.2017.12.016. Epub 2018 Jan 11.
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Detection of promoter hypermethylation in salivary rinses as a biomarker for head and neck squamous cell carcinoma surveillance.唾液冲洗液中启动子超甲基化的检测作为头颈部鳞状细胞癌监测的生物标志物。
Clin Cancer Res. 2011 Jul 15;17(14):4782-9. doi: 10.1158/1078-0432.CCR-11-0324. Epub 2011 May 31.
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Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.通过癌症基因靶向测序确定的头颈部鳞状细胞癌的基因组改变。
Ann Oncol. 2015 Jun;26(6):1216-1223. doi: 10.1093/annonc/mdv109. Epub 2015 Feb 23.
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Promoter methylation in head and neck tumorigenesis.头颈部肿瘤发生过程中的启动子甲基化
Methods Mol Biol. 2012;863:187-206. doi: 10.1007/978-1-61779-612-8_11.
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Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中常见的肿瘤相关基因启动子高甲基化。
Oncol Rep. 2009 Dec;22(6):1519-26. doi: 10.3892/or_00000596.
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Cytogenetic alterations and their molecular genetic correlates in head and neck squamous cell carcinoma: a next generation window to the biology of disease.头颈部鳞状细胞癌中的细胞遗传学改变及其分子遗传学关联：洞察疾病生物学的新一代窗口。
Genes Chromosomes Cancer. 2014 Dec;53(12):972-90. doi: 10.1002/gcc.22214. Epub 2014 Sep 3.
引用本文的文献
1
Methylation related genes are associated with prognosis of patients with head and neck squamous cell carcinoma via altering tumor immune microenvironment.甲基化相关基因通过改变肿瘤免疫微环境与头颈部鳞状细胞癌患者的预后相关。
J Dent Sci. 2023 Jan;18(1):57-64. doi: 10.1016/j.jds.2022.07.010. Epub 2022 Aug 5.
2
High eukaryotic initiation factor 5A2 expression predicts poor prognosis and may participate in the SNHG16/miR-10b-5p/EIF5A2 regulatory axis in head and neck squamous cell carcinoma.高真核起始因子 5A2 的表达预示着不良预后，可能参与了头颈部鳞状细胞癌中的 SNHG16/miR-10b-5p/EIF5A2 调控轴。
J Clin Lab Anal. 2023 Jan;37(1):e24820. doi: 10.1002/jcla.24820. Epub 2022 Dec 22.
3
Prognostic and therapeutic prediction by screening signature combinations from transcriptome-methylome interactions in oral squamous cell carcinoma.通过筛选口腔鳞状细胞癌转录组-甲基化组相互作用中的特征组合进行预后和治疗预测。
Sci Rep. 2022 Jul 6;12(1):11400. doi: 10.1038/s41598-022-15534-7.
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Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas.头颈部鳞状细胞癌中上皮-间质转化衍生的异质性
Cancers (Basel). 2021 Oct 26;13(21):5355. doi: 10.3390/cancers13215355.
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Early-Phase Interventional Trials in Oral Cancer Prevention.口腔癌预防的早期干预试验
Cancers (Basel). 2021 Jul 30;13(15):3845. doi: 10.3390/cancers13153845.
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Methylation-Driven Genes Identified as Novel Prognostic Indicators for Thyroid Carcinoma.甲基化驱动基因被鉴定为甲状腺癌的新型预后指标。
Front Genet. 2020 Mar 31;11:294. doi: 10.3389/fgene.2020.00294. eCollection 2020.
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DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.DNA甲基化介导的Klotho基因沉默是头颈部鳞状细胞癌的独立预后生物标志物。
Cancer Manag Res. 2019 Feb 12;11:1383-1390. doi: 10.2147/CMAR.S188415. eCollection 2019.
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DNA methylation biomarkers for head and neck squamous cell carcinoma.头颈部鳞状细胞癌的 DNA 甲基化生物标志物。
Epigenetics. 2018;13(4):398-409. doi: 10.1080/15592294.2018.1465790. Epub 2018 Aug 10.
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Deciphering the Role of the Barr Body in Malignancy: An insight into head and neck cancer.解读巴氏小体在恶性肿瘤中的作用：对头颈部癌症的深入洞察
Sultan Qaboos Univ Med J. 2017 Nov;17(4):e389-e397. doi: 10.18295/squmj.2017.17.04.003. Epub 2018 Jan 10.
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Analysis of Site-Specific Methylation of Tumor-Related Genes in Head and Neck Cancer: Potential Utility as Biomarkers for Prognosis.头颈部癌中肿瘤相关基因位点特异性甲基化分析：作为预后生物标志物的潜在效用
Cancers (Basel). 2018 Jan 22;10(1):27. doi: 10.3390/cancers10010027.
本文引用的文献
1
Neighborhood-specific epigenome analysis: the pathway forward to understanding gene-environment interactions.特定邻里环境的表观基因组分析：通向理解基因-环境相互作用的前进道路。
N C Med J. 2011 Mar-Apr;72(2):125-7.
2
Consistent DNA hypermethylation patterns in laryngeal papillomas.喉乳头状瘤中一致的DNA高甲基化模式。
Int J Head Neck Surg. 2010 May;1(2):69-77. doi: 10.5005/jp-journals-10001-1013.
3
DNA hypermethylation markers of poor outcome in laryngeal cancer.喉癌预后不良的DNA高甲基化标志物
Clin Epigenetics. 2010 Sep 1;1(1-2):61-69. doi: 10.1007/s13148-010-0005-3.
4
Head and neck cancer: response to p53-based therapeutics.头颈部癌症：p53 靶向治疗的反应。
Head Neck. 2011 Jan;33(1):131-4. doi: 10.1002/hed.21364.
5
Treatment with demethylating agent, 5-aza-2'-deoxycytidine enhances therapeutic HPV DNA vaccine potency.使用去甲基化剂5-氮杂-2'-脱氧胞苷进行治疗可增强治疗性人乳头瘤病毒（HPV）DNA疫苗的效力。
Vaccine. 2009 Jul 9;27(32):4363-9. doi: 10.1016/j.vaccine.2009.02.041. Epub 2009 Feb 24.
6
Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma.多个基因的甲基化作为原发性头颈部鳞状细胞癌的诊断和治疗标志物
Arch Otolaryngol Head Neck Surg. 2007 Nov;133(11):1131-8. doi: 10.1001/archotol.133.11.1131.
7
Epigenetic events underlie the pathogenesis of sinonasal papillomas.表观遗传事件是鼻窦乳头状瘤发病机制的基础。
Mod Pathol. 2007 Oct;20(10):1019-27. doi: 10.1038/modpathol.3800944. Epub 2007 Aug 3.
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An epigenetically derived monoclonal origin for recurrent respiratory papillomatosis.复发性呼吸道乳头状瘤病的表观遗传衍生单克隆起源
Arch Otolaryngol Head Neck Surg. 2007 Jul;133(7):684-92. doi: 10.1001/archotol.133.7.684.
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Epigenetic events of disease progression in head and neck squamous cell carcinoma.头颈部鳞状细胞癌疾病进展中的表观遗传事件。
Arch Otolaryngol Head Neck Surg. 2006 Jun;132(6):668-77. doi: 10.1001/archotol.132.6.668.
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Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.对头颈部鳞状细胞癌中CDKN2B（p15INK4b）、CDKN2A（p14ARF、p16INK4a）和MTAP基因的基因结构精细定位缺失。
Arch Otolaryngol Head Neck Surg. 2006 Apr;132(4):409-15. doi: 10.1001/archotol.132.4.409.
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