Royo Herrero M, Mellado Romero A, Martínez Calatayud J
Departamento de Quimica Analitica, Universidad de Valencia, Valencia, Spain.
Talanta. 1998 Sep;47(1):223-8. doi: 10.1016/s0039-9140(98)00069-1.
The determination of metoclopramide hydrochloride is spectrophotometrically determined by the Bratton-Marshall method in a flow injection assembly. The required nitrite is prepared on-line in the flow assembly by reducing a nitrate solution with the aid of a copperised cadmium solid-phase reactor. The calibration graph is linear over the range 0.5-85 mg l(-1), with a relative standard deviation (RSD) of 0.89%, and sample throughput of 51 samples h(-1). The method is easy and simple, and it is applied to determination of metoclopramide in some pharmaceutical formulations. The method eliminates the need for frequent preparation of unstable nitrite solutions.
