Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain.
Talanta. 1999 Sep 13;50(2):401-7. doi: 10.1016/s0039-9140(99)00126-5.
A simple, selective and sensitive heavy atom-induced room temperature phosphorimetric method (HAI-RTP) is described for the determination of naproxen (NAP) in pharmaceutical preparations. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, in presence of a heavy atom salt and sodium sulfite as an oxygen scavenger to minimize RTP quenching. These variables selection constitute the basis of a HAI-RTP method for the determination of naproxen (detection limit 17.6 ng ml(-1); 1.71% relative standard deviation at 250 ng ml(-1)). The method has been applied satisfactorily to the analysis of pharmaceutical preparations.
本文描述了一种简单、选择性好、灵敏度高的室温磷光法（HAI-RTP），用于测定药物制剂中的萘普生（NAP）。磷光信号是由于在重原子盐和亚硫酸钠（作为氧清除剂）存在下，分析物分子间保护的结果，可最大限度地减少 RTP 猝灭。这些变量的选择构成了一种用于测定萘普生的 HAI-RTP 方法的基础（检测限为 17.6ngml(-1)；在 250ngml(-1)时相对标准偏差为 1.71%）。该方法已成功应用于药物制剂的分析。
