用于测定药物制剂中萘甲唑啉的室温磷光法。
Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations.
作者信息
Segura Carretero A, Cruces Blanco C, Cañabate Díaz B, Fernández Gutiérrez A
机构信息
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Spain.
出版信息
Analyst. 1998 May;123(5):1069-71. doi: 10.1039/a708672e.
A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TINO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml-1 and a relative standard deviation of 3.74% at the 500 ng ml-1 level. The method was applied to the analysis of pharmaceutical preparations.
描述了一种用于测定药物制剂中萘甲唑啉的选择性和灵敏的胶束稳定室温磷光法（MS-RTP）。该方法基于使用胶束剂（十二烷基硫酸钠）、重原子盐（硝酸铊）和脱氧剂（亚硫酸钠）从萘甲唑啉获得磷光信号。对各种条件的优化使得能够建立一种用于测定萘甲唑啉的MS-RTP方法，其检测限为64.2 ng ml-1，在500 ng ml-1水平下相对标准偏差为3.74%。该方法应用于药物制剂的分析。
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