使用分子印迹聚合物作为识别元件测定乙胺嘧啶的体声波传感器。

Bulk acoustic wave sensor using molecularly imprinted polymers as recognition elements for the determination of pyrimethamine.

作者信息

Peng H, Liang C, He D, Nie L, Yao S

机构信息

College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.

出版信息

Talanta. 2000 Jun 30;52(3):441-8. doi: 10.1016/s0039-9140(00)00393-3.

DOI:10.1016/s0039-9140(00)00393-3

PMID:18968003

Abstract

A new bulk acoustic wave (BAW) sensor modified with a molecularly imprinted polymer (MIP) was fabricated and applied for the determination of pyrimethamine. This sensor exhibited high selectivity and sensitive response to pyrimethamine. Factors such as pH and the amount of coating influencing sensor properties, were investigated in detail and optimized. The calibration curve was linear in the range 6.0x10(-7)-1.0x10(-4) M. The determination limit was 2.0x10(-7) M. In harsh chemical environments such as high temperature, organic solvents, bases, acids, etc., the sensor still exhibited long-term stability. The proposed method has been satisfactorily applied for the determination of pyrimethamine in serum and urine media.

摘要

制备了一种用分子印迹聚合物（MIP）修饰的新型体声波（BAW）传感器，并将其应用于乙胺嘧啶的测定。该传感器对乙胺嘧啶表现出高选择性和灵敏响应。详细研究并优化了诸如pH值和涂层量等影响传感器性能的因素。校准曲线在6.0×10⁻⁷ - 1.0×10⁻⁴ M范围内呈线性。测定限为2.0×10⁻⁷ M。在高温、有机溶剂、碱、酸等恶劣化学环境中，该传感器仍表现出长期稳定性。所提出的方法已成功应用于血清和尿液介质中乙胺嘧啶的测定。