Hansen B U, Eriksson S, Lindgren S
Dept. of Medicine Malmö, University of Lund, Malmö General Hospital, Sweden.
Scand J Gastroenterol. 1991 Jul;26(7):707-13. doi: 10.3109/00365529108998588.
We used HEp-2 cells to compare the occurrence of multiple nuclear dot (MND), anti-centromere (ACA), and mitotic spindle antibodies (MSA) in patients with primary biliary cirrhosis (PBC) (n = 32) and primary Sjögren's syndrome (n = 50). The predictive value of these antibodies for autoimmune liver disease was evaluated among patients with chronic liver or inflammatory connective tissue diseases. MND were found in 6%, ACA in 10%, and MSA in 6% of PBC sera. Among patients with primary Sjögren's syndrome, ACA were found in one, whereas another had both MND and MSA. MND were also detected in 1 of 25 sera from patients with other chronic inflammatory connective tissue diseases. Reexamination of these three patients showed evidence of PBC in two. In a blinded study of sera from 356 patients with chronic liver diseases, MND were detected in 10 (3%), ACA in 2 (0.9%), and MSA in 4 (1.2%). All patients with MND or ACA and two of four with MSA had PBC or autoimmune chronic active hepatitis, particularly of the cholestatic type. In four of these patients the liver disease had not previously been classified. We conclude that these antibodies have low sensitivity but high predictive value for autoimmune, cholestatic liver disease.
我们使用人喉表皮样癌细胞（HEp-2细胞）比较了原发性胆汁性肝硬化（PBC）患者（n = 32）和原发性干燥综合征患者（n = 50）中多核点（MND）、抗着丝点抗体（ACA）和有丝分裂纺锤体抗体（MSA）的出现情况。在慢性肝病或炎性结缔组织病患者中评估了这些抗体对自身免疫性肝病的预测价值。在PBC患者血清中，6%发现有MND，10%发现有ACA，6%发现有MSA。在原发性干燥综合征患者中，1例发现有ACA，另1例同时有MND和MSA。在其他慢性炎性结缔组织病患者的25份血清中，也有1份检测到MND。对这3例患者的复查显示，其中2例有PBC证据。在一项对356例慢性肝病患者血清的盲法研究中，检测到10例（3%）有MND，2例（0.9%）有ACA，4例（1.2%）有MSA。所有有MND或ACA的患者以及4例有MSA的患者中的2例患有PBC或自身免疫性慢性活动性肝炎，尤其是胆汁淤积型。在这些患者中，有4例之前肝病未分类。我们得出结论，这些抗体对自身免疫性胆汁淤积性肝病敏感性低但预测价值高。
