Chan H L, Lee Y S, Hong H S, Kuo T T
Department of Dermatology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan.
Clin Exp Dermatol. 1994 Jul;19(4):298-302. doi: 10.1111/j.1365-2230.1994.tb01199.x.
Sera from 3528 patients with autoimmune disease, and non-autoimmune disease, and 500 normal individuals were studied for the presence of anticentromere antibodies (ACA) by indirect immunofluorescence on HEP-2 cells. Sixty-seven specimens were identified showing discrete speckled staining: 55 (82.1%), 11 (16.4%), and one (1.5%), were from patients with autoimmune disease, non-autoimmune disease and normal control subjects, respectively. These ACA were present frequently in CREST syndrome (55%), Raynaud's disease (29.6%) and primary biliary cirrhosis (30%). Only 16.4% of the antibody positive patients carried a clinical diagnosis of CREST, which means that ACA are not specific for CREST syndrome. High antibody titre persisted irrespective of whether or not the patients had active disease. The ACA were present infrequently in Sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, immune thrombocytopenic purpura, Graves' disease, immune haemolytic anaemia, and vitiligo. Sera from 107 patients with various other autoimmune diseases were negative for ACA.
通过对HEP-2细胞进行间接免疫荧光检测，研究了3528例自身免疫性疾病患者、非自身免疫性疾病患者以及500名正常个体血清中抗着丝粒抗体（ACA）的存在情况。共鉴定出67份标本呈现离散斑点状染色：其中55份（82.1%）、11份（16.4%）和1份（1.5%）分别来自自身免疫性疾病患者、非自身免疫性疾病患者和正常对照者。这些ACA在CREST综合征（55%）、雷诺病（29.6%）和原发性胆汁性肝硬化（30%）中频繁出现。仅16.4%的抗体阳性患者临床诊断为CREST，这意味着ACA并非CREST综合征所特有。无论患者是否患有活动性疾病，高抗体滴度均持续存在。ACA在干燥综合征、系统性红斑狼疮、类风湿关节炎、免疫性血小板减少性紫癜、格雷夫斯病、免疫性溶血性贫血和白癜风中出现频率较低。107例患有其他各种自身免疫性疾病的患者血清中ACA呈阴性。
