基于某些苯甲酰胺对铈-亚硫酸盐反应的增敏作用的流动注射化学发光分析法

Flow-injection chemiluminometric analysis of some benzamides by their sensitizing effect on the cerium-sulphite reaction.

作者信息

Aly F A, Alarfaj N A, Alwarthan A A

机构信息

Department of Chemistry, College of Science, King Saud University (Girls), P.O. Box 22452, Riyadh 11495, Saudi Arabia.

出版信息

Talanta. 2001 May 30;54(4):715-25. doi: 10.1016/s0039-9140(01)00320-4.

DOI:10.1016/s0039-9140(01)00320-4

PMID:18968294

Abstract

A simple, highly sensitive chemiluminescent method using flow injection is described for the determination of three substituted benzamides, namely: sulpiride, sultopride and tiapride. The method is based on the sensitizing effect of these drugs on the chemiluminometric oxidation of sulphite by cerium(IV). The different experimental parameters affecting the chemiluminescence intensity were carefully studied and incorporated into the procedure. The method permits the determination of 0.05-2.5 mug ml(-1) sulpiride, 0.01-2.5 mug ml(-1) sultopride hydrochloride and 0.01-1.5 mug ml(-1) tiapride hydrochloride with minimum detectability of 0.01 mug ml(-1). The method was applied to the determination of these benzamides in pharmaceutical preparations and biological fluids.

摘要

本文描述了一种使用流动注射的简单、高灵敏度化学发光法，用于测定三种取代苯甲酰胺，即舒必利、舒托必利和硫必利。该方法基于这些药物对铈（IV）氧化亚硫酸盐化学发光测定的增敏作用。仔细研究了影响化学发光强度的不同实验参数，并将其纳入测定程序。该方法可测定0.05 - 2.5μg ml⁻¹的舒必利、0.01 - 2.5μg ml⁻¹的盐酸舒托必利和0.01 - 1.5μg ml⁻¹的盐酸硫必利，最低检测限为0.01μg ml⁻¹。该方法已应用于药物制剂和生物流体中这些苯甲酰胺的测定。