Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Science, Beni-Suef University, Beni-Suef, Egypt.
Sci Rep. 2020 May 25;10(1):8607. doi: 10.1038/s41598-020-65592-y.
Novel multiwalled carbon nanotubes/ Fe-Co doped titanate nanotubes nanocomposite (MWCNTs/Fe-Co doped TNTs) facilitated the charge transfer and enhanced sensitivity and selectivity. Herein, three novel modified carbon paste sensors (CPSs) based on MWCNTs (sensor I), Fe-Co doped TNTs (sensor II) and MWCNTs/Fe-Co doped TNTs composite (sensor III) were fabricated for a simple, low cost and high accuracy electrochemical method for the potentiometric determination of sulpiride (SLP). The sensors exhibited excellent Nernstian slopes 57.1 ± 0.4, 56 ± 0.5 and 58.8 ± 0.2 mV decade with detection limits (DL) 7.6 × 10, 1.58 × 10 and 8.7 × 10 mol L, quantification limits (QL) 2.5 × 10, 5.2 × 10 and 2.9 × 10 mol L for a long lifetime 20, 18, and 25 weeks for sensors (I), (II), and (III), respectively. The modified sensor (III) was applicable by measuring the concentration of spiked SLP in pure solutions, pharmaceutical products, human urine, and real water samples. The proposed method can be used as an important analytical tool in the quality control of the pharmaceutical industry.
新型多壁碳纳米管/Fe-Co 掺杂钛酸盐纳米管纳米复合材料（MWCNTs/Fe-Co 掺杂 TNTs）促进了电荷转移，提高了灵敏度和选择性。在此，制备了三种基于 MWCNTs（传感器 I）、Fe-Co 掺杂 TNTs（传感器 II）和 MWCNTs/Fe-Co 掺杂 TNTs 复合材料（传感器 III）的新型修饰碳糊电极传感器（CPS），用于简单、低成本和高精度的电化学方法电位法测定奋乃静（SLP）。传感器表现出优异的 Nernst 斜率 57.1±0.4、56±0.5 和 58.8±0.2 mV decade，检测限（DL）为 7.6×10、1.58×10 和 8.7×10 mol L，定量限（QL）为 2.5×10、5.2×10 和 2.9×10 mol L，传感器（I）、（II）和（III）的寿命分别为 20、18 和 25 周。修饰后的传感器（III）可通过测量纯溶液、药物制剂、人尿和实际水样中 SLP 的浓度来应用。该方法可作为制药工业质量控制的重要分析工具。
