Ion Track Instruments, Wilmington, MA 01887, USA.
Talanta. 2002 Apr 22;57(1):123-34.
A novel analysis of explosives via the coupling of an airline passenger personnel portal with a high-flow (HF), high-resolution (HR) ion mobility spectrometry (IMS) was shown for the first time. The HF-HR-IMS utilized a novel ion aperture grid design with a (63)Ni ionization source while operating at ambient pressure in the positive ion mode at 200 degrees C. The HF-HR-IMS response characteristics of 2,4,6-trinitrotoluene (TNT), 4,6-dinitro-o-cresol (4,6DNOC), and cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX) were investigated. Modifications made to the HF-HR-IMS exhaust and ionization source created an 800% increase in the total ion current (TIC), from 0.85 to 6.8 nA. This translated into a 65% ion response increase for TNT when compared with a traditional IMS. A mixture of TNT and (4,6DNOC) was used to successfully demonstrate the resolving power of the species with similar reduced mobility constants (K(o)), 1.54 and 1.59, respectively. The reactant ion (H(2)O)(n)H(+), peak was also used to measure the resolving power of the spectrometer while varying the internal diameter of three different aperture openings from 1.00 to 3.54cm. This provided a resolving power range of 50-60, double that typically achievable by commercial IMS instruments. Most important, these changes made in this new instrumental design can be implemented to all existing and future IMS's to greatly enhance the achievable IMS resolving power.
首次展示了一种通过将航空公司旅客人员门户与高流量（HF）、高分辨率（HR）离子迁移谱（IMS）耦合进行爆炸物分析的新方法。HF-HR-IMS 采用了带有（63）Ni 电离源的新型离子孔径栅格设计，在正离子模式下以 200°C 的环境压力操作。研究了 2,4,6-三硝基甲苯（TNT）、4,6-二硝基邻甲酚（4,6DNOC）和环-1,3,5-三亚甲基-2,4,6-三硝胺（RDX）在 HF-HR-IMS 中的响应特性。HF-HR-IMS 排气和电离源的改进使总离子电流（TIC）增加了 800%，从 0.85 增加到 6.8 nA。与传统 IMS 相比，这导致 TNT 的离子响应增加了 65%。使用 TNT 和（4,6DNOC）混合物成功地证明了具有相似的迁移率常数（K(o)）的物质的分辨能力，分别为 1.54 和 1.59。还使用反应物离子（H(2)O)(n)H(+)峰来测量光谱仪的分辨能力，同时改变三个不同孔径开口的内径从 1.00 到 3.54cm。这提供了 50-60 的分辨能力范围，是商业 IMS 仪器通常可实现的两倍。最重要的是，这种新仪器设计中的这些更改可以应用于所有现有的和未来的 IMS，以大大提高可实现的 IMS 分辨能力。
