Department of Chemistry, Institute of Analytical Sciences, Southwest Normal University, Beibei, Chongqing 400715, People's Republic of China.
Talanta. 2002 Jul 3;57(5):953-9. doi: 10.1016/s0039-9140(02)00142-x.
A new chemiluminescence (CL) method is proposed for the determination of chlorpromazine hydrochloride, a drug often used to treat the psychiatric patients suffering from clinical depression. The method is based on the reaction between studied drug and Ce(IV) in a nitric acid medium and measurement of the CL intensity produced by rhodamine 6G used as a sensitizer. In the optimum conditions, CL intensities are proportional to concentrations of the studied drug over the range 0-1x10(-5) g ml(-1) with a detection limit of 6.5x10(-9) g ml(-1). The relative standard deviation (R.S.D.) is 4.1% for 1.5x10(-6) g ml(-1) chlorpromazine hydrochloride (n=11). The method has been applied to the determination of studied drug in tablets and biological fluids with satisfactory results.
提出了一种新的化学发光（CL）方法，用于测定盐酸氯丙嗪，这是一种常用于治疗患有临床抑郁症的精神病患者的药物。该方法基于研究药物与 Ce(IV)在硝酸介质中的反应，以及测量用作敏化剂的罗丹明 6G 产生的 CL 强度。在最佳条件下，CL 强度与研究药物的浓度在 0-1x10(-5) g ml(-1)范围内成正比，检测限为 6.5x10(-9) g ml(-1)。对于 1.5x10(-6) g ml(-1)的盐酸氯丙嗪，相对标准偏差（R.S.D.）为 4.1%（n=11）。该方法已应用于片剂和生物体液中研究药物的测定，结果令人满意。
