Department of Chemistry, Isfahan University of Technology, Isfahan 84154, Iran.
Talanta. 2004 Jan 9;62(1):65-70. doi: 10.1016/S0039-9140(03)00401-6.
The separation efficiency of ion mobility spectrometry (IMS) may be measured in terms of either resolving power, based on a single-peak definition, or peak-to-peak resolution, based on the separation of pairs of adjacent peaks. Usually resolving power decreases with temperature. However, the experimental results show that the peak-to-peak resolution may be increased in some cases. Negative ion mobility spectra of halide ions are better resolved at elevated temperatures. In addition, the peaks corresponding to protonated monomer of amylacetate and the proton-bound dimer of ethylacetate are well separated at 100 degrees C while they fully overlap at 18 degrees C. This paper focuses on the effect of temperature on peak-to-peak resolution. It was also observed that in some cases peak-to-peak resolution decreases with temperature. Examples are the spectra of cyclohexanone and methyl-iso-butyl ketone (MIBK) as well as dimethyl methyl phosphonate (DMMP) and MIBK. The increase or decrease in resolution at elevated temperatures has been attributed to the changes in separation factor (alpha) which is governed by the different hydration and clustering tendency of ions.
离子淌度谱（IMS）的分离效率可以根据单峰定义的分辨率或基于相邻峰对分离的峰到峰分辨率来衡量。通常，分辨率随温度降低而降低。然而，实验结果表明，在某些情况下，峰到峰分辨率可能会增加。卤化物负离子的负离子淌度谱在高温下得到更好的分离。此外，在 100°C 时，与乙酸戊酯的质子化单体和乙酸乙酯的质子结合二聚体对应的峰完全重叠，而在 18°C 时它们很好地分离。本文重点研究了温度对峰到峰分辨率的影响。还观察到在某些情况下，峰到峰分辨率随温度降低而降低。例如环己酮和甲基异丁基酮（MIBK）以及二甲基甲基膦酸酯（DMMP）和 MIBK 的光谱。在高温下分辨率的增加或降低归因于分离因子（alpha）的变化，分离因子受离子的不同水合和聚集倾向的影响。
