Skrzypek Sławomira, Ciesielski Witold, Sokołowski Adam, Yilmaz Selahattin, Kaźmierczak Dorota
Department of Instrumental Analysis, University of Łódź, Pomorska 163, 90236 Łódź, Poland.
Talanta. 2005 Jun 15;66(5):1146-51. doi: 10.1016/j.talanta.2005.01.017.
Electrochemical studies of famotidine were carried out using voltammetric techniques: cyclic voltammetry, linear sweep and square wave adsorptive stripping voltammetry. The dependence of the current on pH, buffer concentration, nature of the buffer, and scan rate was investigated. The best results for the determination of famotidine were obtained in MOPS buffer solution at pH 6.7. This electroanalytical procedure enabled to determine famotidine in the concentration range 1x10(-9)-4x10(-8)molL(-1) by linear sweep adsorptive stripping voltammetry (LS AdSV) and 5x10(-10)-6x10(-8)molL(-1) by square wave adsorptive stripping voltammetry (SW AdSV). Repeatability, precision and accuracy of the developed methods were checked. The detection and quantification limits were found to be 1.8x10(-10) and 6.2x10(-10)molL(-1) for LS AdSV and 4.9x10(-11) and 1.6x10(-10)molL(-1) for SW AdSV, respectively. The method was applied for the determination of famotidine in urine.
循环伏安法、线性扫描伏安法和方波吸附溶出伏安法。研究了电流对pH值、缓冲液浓度、缓冲液性质和扫描速率的依赖性。在pH值为6.7的MOPS缓冲溶液中，法莫替丁的测定结果最佳。该电分析方法能够通过线性扫描吸附溶出伏安法（LS AdSV）在1×10（-9）-4×10（-8）molL（-1）浓度范围内测定法莫替丁，通过方波吸附溶出伏安法（SW AdSV）在5×10（-10）-6×10（-8）molL（-1）浓度范围内测定法莫替丁。对所建立方法的重复性、精密度和准确性进行了检验。发现LS AdSV的检测限和定量限分别为1.8×10（-10）和6.2×10（-10）molL（-1），SW AdSV的检测限和定量限分别为4.9×10（-11）和1.6×10（-10）molL（-1）。该方法应用于尿液中法莫替丁的测定。
