Mohamed A O, Ronquist G
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Ups J Med Sci. 1991;96(1):23-33. doi: 10.3109/03009739109179256.
Twelve patients suffering from sickle cell anaemia (Hb less than 75 g/l) with SS-haemoglobin were studied with special regard to Band 3-protein content in their erythrocyte membranes on SDS-PAGE. They were compared in this respect with 7 asymptomatic individuals with AS-haemoglobin and 10 healthy controls with the ordinary adult haemoglobin. A heterogeneity in Band 3-protein content was evident among the 12 patients. Six of them belonged to a low content group while the other 6 belonged to a high content group comparable with the asymptomatic subjects and the controls. No simple relationship seemed to exist between Band 3-protein reduction and the clinical presentation.
对12例患有镰状细胞贫血（血红蛋白低于75 g/l）且血红蛋白为SS型的患者进行了研究，特别关注其红细胞膜在SDS-PAGE上的带3蛋白含量。在这方面，将他们与7例血红蛋白为AS型的无症状个体以及10例具有正常成人血红蛋白的健康对照进行了比较。12例患者中带3蛋白含量存在异质性。其中6例属于低含量组，另外6例属于高含量组，后者与无症状个体和对照组相当。带3蛋白减少与临床表现之间似乎不存在简单的关系。
