Johns A, Tasker J J, Johnson C E, Theman M A, Paton D M
Arch Int Pharmacodyn Ther. 1976 Nov;224(1):109-13.
Dicyclomine inhibited responses of rabbit detrusor muscle to transmural stimulation more than atropine or lidocaine, and also inhibited responses to acetylcholine and to KCl. Responses of rabbit vas deferens to noradrenaline and transmural stimulation were inhibited by dicyclomine. Dicyclomine was as potent a local anesthetic as lidocaine, as determined by the guinea-pig wheal test. 45Ca++ exchange in the rabbit detrusor, measured by the lanthanum methods, was not altered by atropine, lidocaine or dicyclomine. It is concluded that dicyclomine not only acts as an anticholinergic agent but also impairs excitation-contraction coupling and release of transmitter from autonomic nerves.
双环胺对兔逼尿肌跨壁刺激反应的抑制作用比阿托品或利多卡因更强，并且还抑制对乙酰胆碱和氯化钾的反应。双环胺抑制兔输精管对去甲肾上腺素和跨壁刺激的反应。通过豚鼠风团试验测定，双环胺作为局部麻醉剂与利多卡因效力相当。用镧法测量，阿托品、利多卡因或双环胺均未改变兔逼尿肌中的45Ca++交换。得出的结论是，双环胺不仅作为抗胆碱能药物起作用，而且还损害自主神经的兴奋-收缩偶联和递质释放。
