Vaithiswaran V, Srinivasan K, Kadambari D
Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Trop Gastroenterol. 2008 Apr-Jun;29(2):91-4.
The impact of early enteral nutrition in elective upper gastrointestinal surgery was the focus of this study, with particular reference to its feasibility and benefits.
This prospective study was carried out over 2 years. The study group included 30 patients and the control group had 31patients. Twenty-two patients in each group underwent truncal vagotomy and gastrojejunostomy for chronic duodenal ulcer and gastric outlet obstruction. Eight patients in the study group and nine in the control group underwent gastrectomy for carcinoma stomach. A standard milk-based diet was initiated 12 hours after surgery through a nasojejunal tube. The patients were monitored for side effects of enteral feeding and postoperative infective complications. Nitrogen balance and nutritional parameters like the body weight, serum albumin, and serum transferrin were measured pre and postoperatively.
The groups were comparable with respect to age, sex, and preoperative nutritional factors like body weight, serum albumin, and serum transferrin. The return of bowel sounds and passage of flatus took place significantly earlier in the study group (1.43 vs. 2.81 days). Diarrhoea and abdominal cramps were the significant complications noted in the study group in relation to early enteral feeding. No patient required withdrawal of enteral feeds. They showed a positive nitrogen balance on the fourth postoperative day. The patients in the study group showed significant increase in the serum transferrin level compared with the preoperative level but the serum albumin level was not significantly altered.
Early enteral feeding through the nasojejunal tube following elective upper gastrointestinal surgery is feasible, safe and improves the nutritional status.
本研究聚焦于择期上消化道手术中早期肠内营养的影响,尤其涉及其可行性和益处。
这项前瞻性研究历时2年。研究组有30例患者,对照组有31例患者。每组中22例患者因慢性十二指肠溃疡和胃出口梗阻接受了迷走神经切断术和胃空肠吻合术。研究组8例患者和对照组9例患者因胃癌接受了胃切除术。术后12小时通过鼻空肠管开始给予标准的以牛奶为基础的饮食。对患者进行肠内喂养的副作用和术后感染并发症监测。术前和术后测量氮平衡以及体重、血清白蛋白和血清转铁蛋白等营养参数。
两组在年龄、性别以及体重、血清白蛋白和血清转铁蛋白等术前营养因素方面具有可比性。研究组肠鸣音恢复和排气明显更早(1.43天对2.81天)。腹泻和腹部绞痛是研究组中与早期肠内喂养相关的显著并发症。没有患者需要停止肠内喂养。他们在术后第四天显示出正氮平衡。研究组患者血清转铁蛋白水平较术前显著升高,但血清白蛋白水平无显著变化。
择期上消化道手术后通过鼻空肠管进行早期肠内喂养是可行、安全的,并且能改善营养状况。