Huo Y, Shi H M, Wang M Y, Li X B
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Pharmazie. 2008 Oct;63(10):699-703. doi: 10.1002/chin.200852234.
Radix Inulae is used as a gastric and antibacterial agent in traditional Chinese and Tibetan medicines. Most of its chemical constituents have been identified and include a series of sesquiterpenes with various carbon skeletons such as: eudesmanolide, elemanolide, germacranolide, sesquicaranolide, guaianolide and humulane. Certain organic solvent fractions and sesquiterpenes from Radix Inulae have been found to significantly inhibit the growth of tumor cell strains in vitro. They also show antibacterial, cardiovascular and hypoglycaemic as well as insulin-sensitization activities. The present review summarizes research on the chemistry and biological activity of Radix Inulae.
旋覆花根在传统中药和藏药中用作胃药和抗菌剂。其大部分化学成分已被鉴定出来，包括一系列具有不同碳骨架的倍半萜类化合物，如：桉叶烷型倍半萜内酯、榄香烷型倍半萜内酯、吉马烷型倍半萜内酯、倍半蒈烷型倍半萜内酯、愈创木烷型倍半萜内酯和葎草烷型倍半萜。已发现旋覆花根的某些有机溶剂提取物和倍半萜类化合物在体外能显著抑制肿瘤细胞株的生长。它们还具有抗菌、心血管、降血糖以及胰岛素增敏活性。本综述总结了旋覆花根的化学和生物活性研究。
