Key Food and Pharmacy College, Xuchang University, Xuchang 461000, China.
Molecules. 2024 May 11;29(10):2267. doi: 10.3390/molecules29102267.
The main varieties of recorded in the Chinese Pharmacopoeia are the roots of Tausch or Hance. However, the chemical constituents and biological activities of this herb have not been reviewed. In order to clarify the chemical constituents of the main varieties of this herb and improve the quality of Chinese medicinal material resources, this paper systematically reviewed their chemical constituents and related biological activities. Phytochemical investigations reveal eighty-five compounds including fort y-nine thiophenes (-), eight flavonoids (-), seven caffeic acids and its derivatives (-), eight sesquiterpenoids (-), and thirteen triterpenoids and other compounds (-) were reported from . The review of biological activities suggests that thiophenes are the main secondary metabolites of the medicinal material which exert antitumor, insecticidal and antifungal activities. In addition, caffeic acid and its derivatives and sesquiterpenes are potential active ingredients worthy of further study. This review provides an important scientific basis for the development of active ingredients and resource quality evaluation of .
《中国药典》收载的主要品种为白花前胡或紫花前胡的根。然而，该属植物的化学成分和生物活性尚未得到综述。为阐明该属植物主要品种的化学成分，提高中药材资源质量，本文对其化学成分及相关生物活性进行了系统综述。植物化学研究表明，从白花前胡或紫花前胡中共分离得到 85 个化合物，包括 49 个噻吩类化合物（-）、8 个黄酮类化合物（-）、7 个咖啡酸及其衍生物（-）、8 个倍半萜类化合物（-）和 13 个三萜类化合物及其他化合物（-）。生物活性研究表明，噻吩类化合物是该药材的主要次生代谢产物，具有抗肿瘤、杀虫和抗真菌活性。此外，咖啡酸及其衍生物和倍半萜类化合物是具有进一步研究价值的潜在活性成分。本综述为该属植物的活性成分开发和资源质量评价提供了重要的科学依据。
