Saussele Tanja
Redaktion Medizinische Monatsschrift für Pharmazeuten, Birkenwaldstr 44, 70191 Stuttgart.
Med Monatsschr Pharm. 2008 Oct;31(10):374-7.
Lacosamide (Vimpat) is an aniepileptic drug with a new, dual mode of action. Lacosamide enhances slow inactivation of voltage-gated sodium channels and modulates the collapsin response mediator protein-2 (CRMP-2), a protein, which is part of neuronal signal transduction pathways and which is attributed to neuroprotection. Reduction of seizure frequency could be demonstrated in several clinical studies in patients with partial-onset seizures who received lacosamide in addition to other antiepileptic drugs.
拉科酰胺（万适宁）是一种具有全新双重作用模式的抗癫痫药物。拉科酰胺可增强电压门控性钠通道的缓慢失活，并调节塌陷反应介导蛋白-2（CRMP-2），该蛋白是神经元信号转导通路的一部分，具有神经保护作用。在多项临床研究中，对于接受其他抗癫痫药物治疗的部分性发作患者，加用拉科酰胺后可降低癫痫发作频率。
