Arpornchayanon Olarn, Leerapun Taninnit
Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
J Med Assoc Thai. 2008 Oct;91(10):1609-12.
Giant cell tumor is a benign locally aggressive tumor. The standard treatment is en bloc resection followed by major reconstructive surgery, or extended curettage conjunction with bone grafting or the use of bone cement implantations. Surgical treatment of giant cell tumor at the sacrum is associated with high morbidity, and local recurrence. The authors present a case of giant cell tumor at the sacrum treated with intravenous 4 mg zoledronate every 4 weeks for seven courses followed with curettage and cement implantation. At two years follow-up, the patient had no pain, no neurological deficit, and no local recurrence. The patient's gait was normal. From the present study, the authors demonstrate the effectiveness of zoledronate for treatment of giant cell tumor at the sacrum. It can reduce the morbidity from major surgery.
骨巨细胞瘤是一种局部侵袭性良性肿瘤。标准治疗方法是整块切除，随后进行大型重建手术，或扩大刮除术并结合骨移植或使用骨水泥植入。骶骨骨巨细胞瘤的手术治疗与高发病率和局部复发相关。作者报告了一例骶骨骨巨细胞瘤患者，每4周静脉注射4毫克唑来膦酸，共七个疗程，随后进行刮除术和骨水泥植入。在两年的随访中，患者无疼痛、无神经功能缺损且无局部复发。患者步态正常。从本研究中，作者证明了唑来膦酸治疗骶骨骨巨细胞瘤的有效性。它可以降低大型手术的发病率。
