de Lima Rocha Maria Gabrielle, Faria Fábio Lopes, Souza Maria do Carmo M, Vago Annamaria Ravara, Fernandes Ana Paula, Fernandes Paula Avila
Department of Clinical and Toxicology Analyses, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cancer. 2008 Dec 25;114(6):489-93. doi: 10.1002/cncr.23947.
The human papillomavirus (HPV) is strongly related to cervical cancer and its precursor lesions. However, unlike in the case of women, there are limited data regarding HPV infection in men. Analysis of male HPV infection is frequently hindered by the lack of consistency in collection methods, sample adequacy, and low sensitivity of cytologic analysis.
The objective of the current study was to compare the results of liquid-based cytology and HPV DNA testing through polymerase chain reaction in 99 penile samples collected from men presenting with condyloma acuminate or male partners of HPV-infected women who had attended a public health service in the city of Belo Horizonte, Minas Gerais, Brazil. Classic and nonclassic cytomorphologic signs were adopted to evaluate the presence of HPV infections in penile smears.
HPV DNA was detected in 93 (93.9%) of the 99 samples analyzed. Koilocytosis was detected in 1 smear and nonclassic signs were detected in 23 smears, 22 of which were found to be positive for HPV DNA.
The cytopathologic detection of HPV infection in penile samples collected for liquid-based cytology is low, even when cytologic nonclassic signs are applied, and does not appear to improve the diagnosis of HPV infection in men.
人乳头瘤病毒（HPV）与宫颈癌及其前驱病变密切相关。然而，与女性情况不同，关于男性HPV感染的数据有限。男性HPV感染分析常常因采集方法缺乏一致性、样本充足性以及细胞学分析灵敏度低而受阻。
本研究的目的是比较99份阴茎样本的液基细胞学和通过聚合酶链反应进行的HPV DNA检测结果，这些样本来自巴西米纳斯吉拉斯州贝洛奥里藏特市一家公共卫生服务机构中患有尖锐湿疣的男性或HPV感染女性的男性伴侣。采用经典和非经典细胞形态学特征评估阴茎涂片样本中HPV感染情况。
在分析的99份样本中，93份（93.9%）检测到HPV DNA。1份涂片检测到挖空细胞，23份涂片检测到非经典特征，其中22份HPV DNA检测呈阳性。
即使应用细胞学非经典特征，为液基细胞学采集的阴茎样本中HPV感染的细胞病理学检测率也较低，且似乎无法改善男性HPV感染的诊断。
