Williams Shauna F, Keane-Tarchichi Megan H, Bettica Linda, Dieudonne Arry, Bardeguez Arlene D
Department of Obstetrics, Gynecology, and Women's Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07101, USA.
Am J Obstet Gynecol. 2009 Feb;200(2):149.e1-5. doi: 10.1016/j.ajog.2008.08.020. Epub 2008 Oct 30.
The objective of the study was to review pregnancy and neonatal outcomes among perinatally infected pregnant patients at our institution.
A retrospective review of maternal and neonatal records for all 10 perinatally infected adolescents between 1997 and 2007 was performed. Demographics, CD4 and viral load, antiretroviral treatment, medical comorbidities, pregnancy outcomes, and neonatal human immunodeficiency virus (HIV) status were abstracted.
The median age at first pregnancy was 18.5 years and 70% were African American. The most common comorbidities were hematologic abnormalities (70%) and cervical dysplasia/sexually transmitted infections (STIs) (80%). Initial median CD4 and viral load were 317 cells/mm(3) and 8780 copies/mL, respectively. The median gestational age at delivery was 38 weeks. The most common obstetrical complications were preeclampsia (23%) and premature rupture of membranes/preterm delivery (31%). The cesarean delivery (CD) rate was 62%, with HIV as the indication in 75%. All infants were born alive; 1 was HIV infected.
Despite high rates of STIs, CD, preterm delivery, and hypertensive disorders, perinatal outcomes were favorable.
本研究的目的是回顾我院围产期感染孕妇的妊娠及新生儿结局。
对1997年至2007年间10例围产期感染青少年孕妇的母婴记录进行回顾性分析。提取人口统计学资料、CD4细胞计数和病毒载量、抗逆转录病毒治疗情况、合并症、妊娠结局及新生儿人类免疫缺陷病毒（HIV）感染状况。
首次妊娠的中位年龄为18.5岁，70%为非裔美国人。最常见的合并症为血液系统异常（70%）和宫颈发育异常/性传播感染（STIs）（80%）。初始CD4细胞计数和病毒载量的中位数分别为317个细胞/mm³和8780拷贝/mL。分娩时的中位孕周为38周。最常见的产科并发症为子痫前期（23%）和胎膜早破/早产（31%）。剖宫产率为62%，其中75%以HIV感染为指征。所有婴儿均存活；1例婴儿感染HIV。
尽管性传播感染、剖宫产、早产及高血压疾病发生率较高，但围产期结局良好。
