Fogel W A, Andrzejewski W, Maslinski C
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
Agents Actions. 1991 May;33(1-2):150-3. doi: 10.1007/BF01993152.
Liver dysfunction induced by protocaval anastomosis (PCA) in the rat is associated with a great reduction of hepatic alcohol and aldehyde dehydrogenase activities. Despite this, PCA rats voluntarily drank more alcohol than unoperated rats. When subjected to forced alcohol consumption, shunted rats maintained their exaggerated voluntary alcohol intake whereas unoperated rats developed aversion to alcohol. Hypothalamic levels of both histamine and histidine were very high in PCA rats. When these rats were chronically exposed to alcohol, there was a slight decrease in hypothalamic histidine concentration and consequently a lower histamine content. Chronic exposure to alcohol did not, however, influence hypothalamic tissue levels of histamine or histidine in unoperated rats. In both groups, chronic alcohol treatment exerted a stimulatory effect on hepatic alcohol metabolizing enzymes.
大鼠门腔静脉吻合术（PCA）诱导的肝功能障碍与肝脏酒精和醛脱氢酶活性大幅降低有关。尽管如此，PCA大鼠自愿饮用的酒精比未手术的大鼠更多。当被迫饮酒时，分流大鼠保持其夸张的自愿酒精摄入量，而未手术的大鼠则对酒精产生厌恶。PCA大鼠下丘脑的组胺和组氨酸水平都非常高。当这些大鼠长期接触酒精时，下丘脑组氨酸浓度略有下降，因此组胺含量降低。然而，长期接触酒精并未影响未手术大鼠下丘脑组织中的组胺或组氨酸水平。在两组中，慢性酒精处理对肝脏酒精代谢酶均有刺激作用。
