急性给予乙醇诱导小鼠下丘脑组胺代谢的变化。

Changes in histamine metabolism in the mouse hypothalamus induced by acute administration of ethanol.

作者信息

Itoh Y, Nishibori M, Oishi R, Saeki K

出版信息

J Neurochem. 1985 Dec;45(6):1880-5. doi: 10.1111/j.1471-4159.1985.tb10547.x.

DOI:10.1111/j.1471-4159.1985.tb10547.x

Abstract

The effect of acute ethanol administration on histamine (HA) dynamics was examined in the mouse hypothalamus. The steady-state level of HA did not change after intraperitoneal administration of ethanol (0.5-5 g/kg), whereas the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, increased when 3 and 5 g/kg of ethanol was given. Pargyline hydrochloride (80 mg/kg, i.p.) increased the level of t-MH by 72.2% 90 min after the treatment. Ethanol at any dose given did not significantly affect the t-MH level in the pargyline-pretreated mice. Decrease in the t-MH level induced by metoprine (10 mg/kg, i.p.), an inhibitor of HA-N-methyltransferase, was suppressed by ethanol (5 g/kg), thereby suggesting inhibition of the elimination of brain t-MH. Ethanol (5 g/kg) significantly delayed the depletion of HA induced by (S)-alpha-fluoromethylhistidine (50 mg/kg, i.v.), a specific inhibitor of histidine decarboxylase. Therefore, a large dose of ethanol apparently decreases HA turnover in the mouse hypothalamus.

摘要

研究了急性给予乙醇对小鼠下丘脑组胺（HA）动态变化的影响。腹腔注射乙醇（0.5 - 5 g/kg）后，HA的稳态水平未发生变化，而当给予3 g/kg和5 g/kg乙醇时，脑HA的主要代谢产物 - 甲基组胺（t - MH）水平升高。盐酸帕吉林（80 mg/kg，腹腔注射）在治疗90分钟后使t - MH水平升高72.2%。给予任何剂量的乙醇对经帕吉林预处理的小鼠的t - MH水平均无显著影响。组胺 - N - 甲基转移酶抑制剂美托普利（10 mg/kg，腹腔注射）诱导的t - MH水平降低被乙醇（5 g/kg）抑制，从而提示乙醇抑制了脑t - MH的消除。乙醇（5 g/kg）显著延迟了由组氨酸脱羧酶特异性抑制剂（S）-α-氟甲基组胺（50 mg/kg，静脉注射）诱导的HA耗竭。因此，大剂量乙醇明显降低了小鼠下丘脑的HA周转率。