[Osteoarthritis of the knee joint as a cause of musculoskeletal ambulation disability symptom complex (MADS)].

Osteoarthritis is considered as a chronic disease of the whole joint, including articular cartilage, meniscus, ligament, and peri-articular muscle that may result from multiple pathophysiological mechanisms. Osteoarthritis is a painful and disabling disease that affects millions of patients. Its aetiology is largely unknown, but is most likely multi-factorial. No proven disease-modifying therapy exists for osteoarthritis and current treatment options for chronic osteoarthritic pain are insufficient, but new pharmacotherapeutic options are emerging. Surgical treatment, such as high tibial osteotomy and total knee arthroplasty are chosen for the patient who have severe pain and disabled patient. In recent 10 years, operation cases are increasing in number, but these procedure still have many issues to resolve. Osteoarthritis of the knee joint is one of a major cause of Musculoskeletal Ambulation Disability Symptom Complex (MADS) , and it is important to improve conservative and surgical treatment.