Solhpour Ali, Pourhoseingholi Mohamad Amin, Soltani Fereshteh, Zarghi Afsaneh, Habibi Manijeh, Ghafarnejad Fatemeh, Tajik Zohreh, Rostaminejad Mohammad, Ramezankhani Ali, Zali Mohammad Reza
Research Center For Gastroenterology and Liver Diseases, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Indian J Gastroenterol. 2008 Jul-Aug;27(4):153-5.
An association between obesity and symptoms of gastro-esophageal reflux disease (GERD) has been frequently reported in western societies. A recent study indicated a consistent association between abdominal diameter and reflux-type symptoms in the white population, but no consistent association in the black population or Asians. It is unclear whether an association persists after adjusting for known risk factors of GERD among Asian populations. We did a population-based, cross-sectional interview study to estimate the strength of association between body mass and symptoms of reflux. During interviews, participants completed a valid gastro-esophageal reflux questionnaire. Odds ratio (OR) with 95% confidence interval (CI), calculated by logistic regression with multivariate adjustments for covariates, were the measures of association. Symptoms of reflux at least once a week over the past 3 months were reported by 522 (9.1%) of the 5733 interviewees. Among those who were overweight or obese (BMI> 25 kg/m2), the OR of having symptoms of reflux was 0.88 (95% CI: 0.66-1.16) compared with those who were not overweight or obese. Thus, among Asians, symptoms of GERD occur independently of body mass index.
在西方社会，肥胖与胃食管反流病（GERD）症状之间的关联已屡有报道。最近一项研究表明，在白人人群中，腹围与反流型症状之间存在持续关联，但在黑人人群或亚洲人群中则不存在一致的关联。目前尚不清楚在亚洲人群中，在对已知的GERD危险因素进行校正后，这种关联是否仍然存在。我们开展了一项基于人群的横断面访谈研究，以评估体重与反流症状之间的关联强度。在访谈过程中，参与者完成了一份有效的胃食管反流调查问卷。通过对协变量进行多变量调整的逻辑回归计算得出的比值比（OR）及其95%置信区间（CI），作为关联的衡量指标。在5733名受访者中，有522人（9.1%）报告在过去3个月中每周至少出现一次反流症状。与非超重或肥胖者相比，超重或肥胖（BMI>25 kg/m2）者出现反流症状的OR为0.88（95%CI：0.66 - 1.16）。因此，在亚洲人群中，GERD症状的出现与体重指数无关。
