大鼠腹膜肥大细胞中连接颗粒与细胞膜的细丝的存在。

The existence of filaments connecting the granules and the cell membrane in rat peritoneal mast cells.

作者信息

Tasaka K, Akagi M, Mio M, Miyoshi K, Aoki I

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

出版信息

Agents Actions. 1991 May;33(1-2):48-52. doi: 10.1007/BF01993124.

DOI:10.1007/BF01993124

PMID:1897447

Abstract

SEM images of rat peritoneal mast cells showed that microtubule-like filaments seemed to penetrate the granules and project several branches just beneath the granular surface. Each granule appeared to be a cluster of microgranules. TEM observations frequently revealed microtubules connecting the granule surface to the subplasmalemmal network or to the adjacent granule surface and on some occasions, microtubules also appeared to penetrate the granule membranes. Moreover, TEM revealed that individual granules seemed to consist of a mass of microgranules, each 10-15 nm in diameter; freeze-fracture images showed similar configurations. These findings suggest that the microtubule-like filamentous structures in mast cells play a role corresponding to that of the open canalicular system in platelets.

摘要

大鼠腹膜肥大细胞的扫描电镜图像显示，微管样细丝似乎穿透颗粒并在颗粒表面下方伸出几个分支。每个颗粒似乎是一群微颗粒的聚集体。透射电镜观察经常发现微管将颗粒表面连接到质膜下网络或相邻颗粒表面，并且在某些情况下，微管似乎也穿透颗粒膜。此外，透射电镜显示单个颗粒似乎由大量微颗粒组成，每个微颗粒直径为10 - 15纳米；冷冻蚀刻图像显示出类似的结构。这些发现表明肥大细胞中的微管样丝状结构发挥着与血小板开放小管系统相对应的作用。