Ishiko S, Yoshida A, Hosaka A
Department of Ophthalmology, Asahikawa Medical College, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Jun;95(6):522-9.
We induced myopia by eyelid suturing in one eye each of six 9-month-old cynomolgus monkeys to elucidate the condition by studying changes in the ocular structure and the blood-ocular barrier (BOB) permeability. Optical elements were measured by A-mode ultrasonography; vitreous fluorophotometry was carried out to document BOB permeability before eyelid suturing and 3, 10, 16, and 28 months after suturing. The axial length of the sutured eyes increased significantly compared with that of the non-sutured contralateral eyes at 10 months after suturing and continued to lengthen with time. The dioptric power (D) of the sutured eyes changed in the same way. (mean, -3.08D 28 months after suturing). The permeability of the blood-retinal barrier of the sutured eyes significantly increased from 10 months after suturing compared with that of the fellow eyes, and continued to increase over the period of observation. The permeability index of the blood-aqueous barrier also increased significantly from only 16 months after suturing further increasing as the period of observation lengthened. We hypothesize that in the transition from emmetropia to myopia, the permeability of the BOB rises, and continue to rise as myopia develops. Thus, the breakdown of the BOB, i.e., the breakdown of the ocular homeostasis, is considered to be closely related to the occurrence and the development of myopia.
我们对6只9个月大的食蟹猴每只的一只眼睛进行眼睑缝合以诱发近视，通过研究眼部结构和血眼屏障（BOB）通透性的变化来阐明这种情况。通过A型超声测量光学元件；在眼睑缝合前以及缝合后3、10、16和28个月进行玻璃体荧光光度测定以记录BOB通透性。缝合后10个月时，缝合眼的眼轴长度与未缝合的对侧眼相比显著增加，并随时间持续延长。缝合眼的屈光度（D）也以相同方式变化（缝合后28个月时，平均为-3.08D）。与对侧眼相比，缝合眼的血视网膜屏障通透性从缝合后10个月起显著增加，并在观察期内持续增加。血房水屏障的通透性指数也仅在缝合后16个月起显著增加，并随着观察期延长而进一步增加。我们假设在从正视向近视转变过程中，BOB的通透性升高，并在近视发展过程中持续升高。因此，BOB的破坏，即眼内稳态的破坏，被认为与近视的发生和发展密切相关。
