[衰老对大鼠半乳糖性白内障发生发展的影响]

[The influence of aging on the development of rat galactosemic cataract].

作者信息

Ikebe H, Terubayashi H, Tsutsumi M, Mori K, Akagi Y, Kawasaki N, Tanimoto T

机构信息

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1991 Jun;95(6):538-42.

PMID:1897453

Abstract

In order to investigate the effect of age on the rat galactosemic cataract, 3, 6, 12 and 24-week-old rats were fed with a 50% galactose diet. The cataractous lenses were observed by light microscopy, and the amount of galactitol measured. All rats fed with 50% galactose developed cataracts in the equatorial region. However, the morphological and biochemical development of the galactose cataract in old rats was slower than in young rats. These results suggested that older diabetic patients are less likely to develop diabetic cataract than younger patients.

摘要

为了研究年龄对大鼠半乳糖性白内障的影响，给3周龄、6周龄、12周龄和24周龄的大鼠喂食50%的半乳糖饮食。通过光学显微镜观察白内障晶状体，并测量半乳糖醇的含量。所有喂食50%半乳糖的大鼠在赤道区域均出现了白内障。然而，老年大鼠半乳糖性白内障的形态学和生化发展比年轻大鼠缓慢。这些结果表明，老年糖尿病患者比年轻患者患糖尿病性白内障的可能性更小。