Hu T S, Merola L O, Kuwabara T, Kinoshita J H
Invest Ophthalmol Vis Sci. 1984 May;25(5):603-5.
Rats fed a 50% galactose diet were treated topically in one eye with 1% Sorbinil . The eye treated with Sorbinil remained clear during the following 4-week period. Unexpectedly, the lens of the untreated eye also maintained transparency. Histologically both lenses remained normal. Moreover, the reduced dulcitol levels in the lenses of both eyes were identical. These findings suggest that the effect of topically administered Sorbinil in galactosemic rats was mainly systemic rather than local. Confirmation of this came from the observations that the extent of inhibition of polyol synthesis in these rats was found to be similar in the sciatic nerve, blood, and lens. A reversal of the galactose cataracts also was affected by Sorbinil eye drop treatment.
用含50%半乳糖的饮食喂养的大鼠，一只眼睛局部用1%的索比尼尔治疗。在接下来的4周内，用索比尼尔治疗的眼睛保持清澈。出乎意料的是，未治疗眼睛的晶状体也保持透明。组织学检查显示两个晶状体均保持正常。此外，两只眼睛晶状体中半乳糖醇水平的降低是相同的。这些发现表明，局部应用索比尼尔对半乳糖血症大鼠的作用主要是全身性的而非局部性的。这一点得到了以下观察结果的证实：在这些大鼠的坐骨神经、血液和晶状体中，多元醇合成的抑制程度相似。索比尼尔滴眼液治疗也能使半乳糖性白内障得到逆转。
