Mehendiratta Vaibhav, DiMarino Anthony J, Cohen Sidney
Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Dig Dis Sci. 2009 Jul;54(7):1481-6. doi: 10.1007/s10620-008-0518-1. Epub 2008 Oct 31.
To evaluate the utility of selective esophageal manometry in clinical practice.
Retrospective data from 200 subjects was reviewed. Manometry was considered to be (1) high clinical utility when specific abnormality was identified resulting in therapeutic intervention, (2) low clinical utility when specific abnormality was identified without alteration of therapy, (3) limited clinical utility when manometry was normal. High, low, and limited clinical utility was noted in 47, 40, and 13% of instances. Manometry was of high utility in patients with dysphagia or non-cardiac chest pain (P < 0.05), and low utility in gastroesophageal reflux (P < 0.05).
(1) Esophageal manometry has high clinical utility in dysphagia after exclusion of structural disorders; and non-cardiac chest pain after careful exclusion of reflux. (2) Ineffective motility disorder has high association with gastroesophageal reflux disease but low clinical utility except in preoperative assessment for fundoplication. (3) Esophageal manometry is of high utility in clinical practice when used in conjunction with other diagnostic exclusions.
评估选择性食管测压在临床实践中的效用。
回顾了200名受试者的回顾性数据。当确定特定异常并导致治疗干预时,测压被认为具有(1)高临床效用;当确定特定异常但治疗未改变时,测压被认为具有(2)低临床效用;当测压正常时,测压被认为具有(3)有限的临床效用。在47%、40%和13%的病例中分别观察到高、低和有限的临床效用。测压在吞咽困难或非心源性胸痛患者中具有高效用(P<0.05),在胃食管反流患者中具有低效用(P<0.05)。
(1)排除结构性疾病后,食管测压在吞咽困难患者中具有高临床效用;仔细排除反流后,在非心源性胸痛患者中具有高临床效用。(2)无效动力障碍与胃食管反流病高度相关,但除了在胃底折叠术的术前评估中外,临床效用较低。(3)食管测压与其他诊断排除方法联合使用时,在临床实践中具有高效用。