Tao Huaming, Wang Lishu, Cui Zhanchen, Zhao Daqing, Liu Yonghong
College of Chemistry, Jilin University, Changchun, P. R. China.
Planta Med. 2008 Dec;74(15):1823-5. doi: 10.1055/s-0028-1088321. Epub 2008 Oct 30.
Two new dimeric proanthocyanidins, ephedrannin B ( 2) and mahuannin E ( 4), along with two known congeners, ephedrannin A ( 1) and mahuannin D ( 3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new compounds were deduced to be 5,7,4'-trihydroxyflavan-[4(alpha)-->8,2(alpha)-->O-->7]-kaempferol ( 2) and 5,7,4'-trihydroxyflavan-[4(beta)-->8,2(beta)-->O-->7]- EPI-afzelechin ( 4). The compounds 1 - 4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.
从麻黄（Ephedra sinica Stapf）的根部分离出两种新的二聚体原花青素，麻黄宁B（2）和麻黄酮E（4），以及两种已知的同系物，麻黄宁A（1）和麻黄酮D（3）。基于核磁共振（NMR）、质谱（MS）和圆二色光谱（CD）分析，推断出新化合物的结构分别为5,7,4'-三羟基黄烷-[4(α)→8,2(α)→O→7]-山奈酚（2）和5,7,4'-三羟基黄烷-[4(β)→8,2(β)→O→7]-表阿夫儿茶素（4）。对化合物1 - 4进行了针对三种肿瘤细胞系（SGC - 7901、HepG2和HeLa）的细胞毒性评估，发现化合物2具有显著活性。
