芦笋根中的甾体化合物及其细胞毒性活性。

Steroids from the roots of Asparagus officinalis and their cytotoxic activity.

作者信息

Huang Xue-Feng, Lin Yu-Ying, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

出版信息

J Integr Plant Biol. 2008 Jun;50(6):717-22. doi: 10.1111/j.1744-7909.2008.00651.x.

DOI:10.1111/j.1744-7909.2008.00651.x

PMID:18713412

Abstract

One new (Sarsasapogenin O) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxicities against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

摘要

从芦笋根中分离出一种新的甾体（菝葜皂苷元O）和七种已知甾体。通过光谱分析，包括各种二维核磁共振技术、水解，并与已知化合物的光谱数据进行比较，阐明了它们的结构。对这些化合物以及之前从该植物中分离出的九种甾体进行了细胞毒性活性测试。其中，八种化合物对人A2780、HO-8910、Eca-109、MGC-803、CNE、LTEP-a-2、KB肿瘤细胞和小鼠L1210肿瘤细胞显示出显著的细胞毒性。