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基于多价纳米颗粒催化剂的磷酸二酯和DNA水解

Phosphate diester and DNA hydrolysis by a multivalent, nanoparticle-based catalyst.

作者信息

Bonomi Renato, Selvestrel Francesco, Lombardo Valentina, Sissi Claudia, Polizzi Stefano, Mancin Fabrizio, Tonellato Umberto, Scrimin Paolo

机构信息

Dipartimento di Scienze Chimiche and CNR-ITM, Universita di Padova, Padova, Italy.

出版信息

J Am Chem Soc. 2008 Nov 26;130(47):15744-5. doi: 10.1021/ja801794t.

DOI:10.1021/ja801794t
PMID:18975902
Abstract

2-nm gold nanoclusters coated with Zn(II) complexes bearing auxiliary hydrogen bond donors act as multivalent catalysts capable of promoting the hydrolysis of model phosphate diesters with exceptional activity and inducing DNA double strand cleavage.

摘要

包覆有带有辅助氢键供体的锌（II）配合物的2纳米金纳米团簇作为多价催化剂，能够以非凡的活性促进模型磷酸二酯的水解并诱导DNA双链断裂。

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